Cluster of Excellence, University of Freiburg

CIBSS-A – Molecular Signalling Dynamics

Cells are the fundamental unit of life and are separated from their environment and compartmentalized internally by cellular membranes. By extension, the transmission of information across membranes that is accomplished by cellular signalling is a fundamental process of life. Signalling processes at and across membranes – such as the cell membrane and the nuclear membrane – are thought to be predominantly mediated by multi-protein complexes operating as supra-molecular signalling assemblies. CIBSS investigates how these dynamic signalling machineries perceive, process and transmit signals, and how signalling specificity is achieved through variations in their formation and composition. CIBSS also elucidates how complex networks of signalling assemblies contextualize information and accurately transduce the signals that control cellular fate and function.



Asifa Akhtar

Bernd Fakler

Thomas Laux

Nikolaus Pfanner