Research:

The Emmy Noether independent research group focuses on deciphering the genetic basis of developmental timing and size control in vertebrates. Utilising aquatic model systems, in-vivo quantitative phenotyping, genetic hybridisation, advanced 4D-imaging and multi-omics approaches we aim to uncover the fundamental mechanisms underlying the control of embryonic development tempo and it's link to size in vertebrate embryos. Additionally, the group will continue developing and deploying state-of-the-art quantitative imaging techniques and targeted genome engineering (e.g., CRISPR/Cas9 knock-in approaches) in aquatic models to visualise and spatio-temporally control endogenous protein dynamics in-vivo.

Selected publications:

Modular control of vertebrate axis segmentation in time and space.
Seleit A, Brettell I, Fitzgerald T, Vibe C, Loosli F, Wittbrodt J, Naruse K, Birney E, Aulehla A. The EMBO Journal. 2024

Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach.
Seleit A*, Aulehla A, Paix A. eLife. 2021

Local tissue interactions govern pLL patterning in medaka.
Seleit A, Gross K, Onistschenko J, Hoang O, Theelke J, Centanin L. Developmental Biology. 2022.

Diversity of lateral line patterns and neuromast numbers in the genus Oryzias.
Seleit A, Ansai S, Yamahira K, Kawilarang WAM, Masengi, Naruse K, Centanin L. Journal of Experimental Biology. 2021

Development and regeneration dynamics of the medaka notochord.
Seleit A*, Gross K, Woelk M, Autorino C, Centanin L. Developmental Biology. 2020

Neural stem cells induce the formation of their physical niche during organogenesis.
Seleit A, Krämer I, Riebesehl BF, Ambrosio EM, Stolper JS, Lischik CQ, Dross N, Centanin L. eLife. 2017.

Sequential organogenesis sets two parallel sensory lines in medaka.
Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L. Development. 2017