CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Principal Investigators

Jun. Prof. Dr. David Haselbach

Jun. Prof. Dr. David Haselbach

Contact

Jun. Prof. Dr. David Haselbach
Institute of Physical Chemistry (Faculty of Chemistry and Pharmacy)
University of Freiburg


david.haselbach(at)physchem.uni-freiburg.de

Further Information

10 selected publications

  • The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.
    Rodriguez Carvajal A, Grishkovskaya I, Gomez Diaz C, Vogel A, Sonn-Segev A, Kushwah MS, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, Haselbach D#, Ikeda F# (2021).
    Elife. 18;10:e60660.
  • Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
    Prattes M, Grishkovskaya I, Hodirnau VV, Rössler I, Klein I, Hetzmannseder C, Zisser G, Gruber CC, Gruber K, Haselbach D#, Bergler H# (2021).
    Nat Commun. 12(1):3483.
  • Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
    Ahel J, Lehner A, Vogel A, Schleiffer A, Meinhart A, Haselbach D#, Clausen T# (2020).
    Elife. 9:e56185.
  • Quantifying the heterogeneity of macromolecular machines by mass photometry.
    Sonn-Segev A, Belacic K, Bodrug T, Young G, VanderLinden RT, Schulman BA, Schimpf J, Friedrich T, Dip PV, Schwartz TU, Bauer B Peters JM, Struwe WB, Benesch JLP, Brown NG#, Haselbach D#, Kukura P# (2020).
    Nat Commun. 11(1):1772.
  • Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
    Prajapati S*, Haselbach D*, Wittig S, Patel MS, Chari A, Schmidt C, Stark H, Tittmann K (2019).
    Structure. 27(7):1124-1136.e4.
  • Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
    Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Lührmann R, Stark H (2018).
    Cell. 172(3):454-464.e11.
  • Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
    Haselbach D*, Schrader J*, Lambrecht F, Henneberg F, Chari A, Stark H (2017).
    Nat Commun. 8:15578. d
  • ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.
    Chari A*, Haselbach D*, Kirves JM*, Ohmer J, Paknia E, Fischer N, Ganichkin O, Möller V, Frye JJ, Petzold G, Jarvis M, Tietzel M, Grimm C, Peters JM, Schulman BA, Tittmann K, Markl J, Fischer U, Stark H (2015).
    Nat Methods. 12(9):859-65.
  • Structural determinants and mechanism of mammalian CRM1 allostery.
    Dölker N*, Blanchet CE*, Voß B*, Haselbach D*, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A (2013).
    Structure. 21(8):1350-60.
  • Structural basis for cooperativity of CRM1 export complex formation.
    Monecke T, Haselbach D, Voß B, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R (2013).
    Proc Natl Acad Sci U S A. 110(3):960-5.