Program

Program:

The symposium will take place completely online.

There will be virtual breakout rooms for discussions and also for the poster session, which will take place parallel to the scientific program of the symposium.

 

Monday, 23.11.2020

09:00  

Opening of Symposium Virtual Environment (for orientation)

10:00   Start of the Symposium
10:00 - 10:15   Introduction to Symposium Virtual Environment
10:15 - 10:20               Welcome Address by the Rector of the University of Freiburg, Prof. Kerstin Krieglstein
10:20 - 10:30   Welcome by the CIBSS Speaker Team (Wolfgang Driever, Carola Hunte, Wilfried Weber)
10:30 Session 1: Mitochondria as Integrative Signalling Hubs (Chair: Chris Meisinger)
  10:30 – 10:55 Agnieszka CHACINSKA (Warszaw): “Cytosolic stress responses to mitochondrial protein import stress”
  10:55 – 11:20 Johannes HERRMANN (Kaiserslautern): “Mitochondrial protein biogenesis: A huge challenge for eukaryotic cells”
  11:20 – 11:40 Nora VÖGTLE (Freiburg): “Protective stress signalling upon mitochondrial dysfunction”
  11:40 – 12:05 Jan RIEMER (Cologne): “Regulating mitochondrial biogenesis by cytosolic processing”
  12:05 – 12:10 Flash Talk 1 Caroline LINDAU (Freiburg):” Signal dependent re-organisation of the membrane insertion machinery for mitochondrial beta-barrel proteins”
  12:10 – 12:15 Flash Talk 1 Adinarayana Marada & Corvin Walter (Freiburg): ”Control of the mitochondrial carrier import pathway by the kinase DYRK1A”

 

12:15 - 12:45               General Discussion

12:45 - 13:15               Lunch Break

13:15 - 14:00               Poster Session 1

 

14:00 Session 2: Metabolic Signalling (Chair: Olaf Groß)
  14:00 – 14:25 Jane MELLOR (Oxford): “The nucleus as an integrator of metabolic signals"
  14:25 – 14:50 Hector HERRANZ (Copenhagen): "A fly approach to cancer metabolism"
  14:50 – 15:10 Julia JELLUSOVA (Freiburg): “Immunoglobulin expression shapes the metabolic profile of B cells by regulating ER homeostasis”
  15:10 – 15:35 Douglas GREEN (Memphis): "Twins separated at birth: c-Myc polarization drives divergent fate in dividing T cells"
  15:35 – 15:40 Flash Talk 1 Milena BERTOLOTTI (Freiburg): “How B lymphocytes adapt to metabolic changes: the role of UCP2”
  15:40 – 15:45 Flash Talk 2 Danye QIU (Freiburg): “Capillary Electrophoresis Coupled to Mass Spectrometry with Stable Isotopic Standards Enables the Rapid Analysis of Inositol Phosphates and Pyrophosphates from Cell Culture”

 

15:45 - 16:15                General Discussion

 

16:15 Session 3: Integrative Immune Signalling (Chair: Nina Cabezas-Wallscheid)
  16:15 – 16:40 Cheng ZHU (Atlanta): "PD-1 Suppresses TCR-CD8 Cooperativity in T-cell Antigen Recognition"
  16:40 – 17:05 Mike DUSTIN (Oxford): "T cells on the attack against cancer and infection”
  17:05 – 17:25 Eirini TROMPOUKI (Freiburg): “Transposable elements induce a RIG-I-like receptor-mediated inflammation to regulate hematopoietic stem cell emergence”
  17:25 – 17:50 Anna BIGAS (Barcelona): ”Different contributions of Notch signaling to orchestrate the development of Hematopoietic stem cells ”
  17:50 – 17:55 Flash Talk 1 Kathrin KLÄSENER (Freiburg): “CD20 as a gatekeeper of the resting state of human B cells”
  17:55 – 18:00 Flash Talk 2 Nadine WÖSSNER (Freiburg): “A new motif in the T cell receptor promotes anti-cancer immunotherapy and allows modulation of T-cell activity”

 

18:00 - 18:30                  General Discussion

19:00 - 20:30                  PANEL DISCUSSION: "Clicks, likes and preprints: are we entering a new age of scientific publication?" (Moderation Alaina Levine)

More information

 

Tuesday, 24.11.2020

09:00 Session 4: Signalling Roots (Chair: Thomas Ott)
  09:00 – 09:25 Uta PASZKOWSKI (Cambridge): “Molecular genetics of Arbuscular Mycorrhizal Symbiosis in Cereals"
  09:25 – 09:50 Sabrina SABATINI (Rome): “The dynamics of root zonation development in Arabidopsis Thaliana”
  09:50 – 10:10 Thomas LAUX (Freiburg): “Adaptation of plant stem cells to environmental signals”
  10:10 – 10:35 Christian HARDTKE (Lausanne): “Flux and polarity the the other vascular system”
  10:35 – 11:00 Martin PARNISKE (Munich): "Evolution of the nitrogen-fixing root nodule symbiosis"
  11:00 – 11:05 Flash Talk 1 Casandra SCHENK (Freiburg): „Formation of multi-component receptor assembly required for Root Nodule Symbiosis in heterologous root cell systems”
  11:05 – 11:10 Flash Talk 2 Sascha WAIDMANN (University of Freiburg) "Cytokinin functions as an asymmetric and anti-gravitropic signal in lateral roots"

 

11:10 - 11:40                  General Discussion

 

11:40 Session 5: Signalling in Time and Space (Chair: Anne Classen)
  11:40 – 12:05 Denis DUBOULE (Geneva): “The Logic of Long-Range Hox Genes Transcription”
  12:05 – 12:25 Wolfgang DRIEVER / Jens TIMMER (Freiburg): „Cell-autonomous Notch-independent oscillation of Her6 reveals critical dynamic parameters in neural stem cell regulation”
  12:25 – 12:50 Poul NISSEN (Aarhus): "Always two sides to a story – structure and function of lipid flippases"
  12:50 – 13:15 Corinne HOUART (London): "mRNA Processing Spatio-Temporally Modulates Axonal and Synaptic Protein Distribution and Activity"
  13:15 – 13:20 Flash Talk 1 Geethika AREKATLA (Zurich): „Optogenetic manipulation reveals ERK and AKT signaling dynamics required for ESC differentiation”
  13:20 – 13:25 Flash Talk 2 Marcus ROSENBLATT (Freiburg): “Transcriptional timing control in the early zygotic development of zebrafish disentangled by mathematical modeling”

 

13:25 - 14:05                  General Discussion

14:05 - 14:30                  Lunch Break

 

 

14:30 Session 6: Signalling Integration (Chair: Carola Hunte)
  14:30 – 14:55 Gillian GRIFFITHS (Cambridge): “Regulating the rheostat in killer T cells”
  14:55 – 15:20 Mary MULLINS (Philadelphia): "BMP morphogen signaling in axial patterning"
  15:20 – 15:40 CIBSS AWARD Talk: Bernd FAKLER (Freiburg): " How ion channels are made - biogenesis of AMPA-type glutamate receptors in the ER"
  15:40 – 16:05 Peter WALENTEK (Freiburg):

Temporal integration of Notch signaling in airway epithelial development and remodeling

  16:05 – 16:10 Flash Talk 1 Ramona EMIG (Freiburg): “Mechanosignaling in Human Atrial Fibroblasts: Implications for Cardiac Fibrosis”
  16:10 – 16:15 Flash Talk 2 Svenja ULFERTS (Freiburg): “SARS-CoV-2 infection activates casein kinase II (CK2) and induces formation of virus-containing filopodial protrusions”

 

16:15 - 16:45                 General Discussion

 

16:45 SPOTLIGHT Session: It Takes Two: Data science and Machine Learning to Propel Signalling Research (Chairs: Bettina Warscheid / Clemens Kreutz)
  16:45 - 17:10 Pedro BELTRAO (Cambridge): “Development of computational approaches applied to the study of kinase signalling"
  17:10 - 17:30 Panel Discussion (Rolf Backofen, Barbara Di Ventura, Melanie Börries, Jens Timmer, Thomas Brox, Harald Binder, Bernd Fakler)
  17:30 - 17:50 General Discussion

18:00                               Poster Session 2

19:00                               Virtual Meeting Opportunities

 

Wednesday, 25.11.2020

09:00 Session 7: Control-of-function (Chair: Maja Köhn)
  09:00 – 09:25 Radu ARICESCU (Cambridge): "Mechanisms of human GABAA receptor signalling inferred from structural pharmacology"
  09:25 – 09:50 Ed TATE (London): "Targeting protein modification: from chemical biology to drug discovery"
  09:50 – 10:10 Henrike NIEDERHOLTMEYER (Marburg): „Programming synthetic organelles to organize and control biochemical reactions in biomimetic systems”
  10:10 – 10:35 Matthias LÜTOLF (Lausanne): “Engineering Epithelial Organoid Development”
  10:35 – 10:40 Flash Talk 1 Maximilian HÖRNER (Freiburg): “Gene delivery at single-cell resolution by optically controlling viral transduction”
  10:40 – 10:45 Flash Talk 2 Bernhard HÖRMANN (Freiburg): „Controlling the function of protein phosphatase-1 in heart disease“

 

10:45 - 11:15                 General Discussion

 

11:15 Session 8: Signalling in Organogenesis (Chair: Anna Köttgen)
  11:15 – 11:40 Jan TRAAS (Lyon): "Leaf Morphogenesis: from chemical gradients to mechanical signals"
  11:40 – 12:05 Didier STAINIER (Bad Nauheim): “Biological Robustness: genetic compensation and transcriptional adaptation”
  12:05 – 12:25 CIBSS InteGREATor Award Talk: Jelena TOSIC (Freiburg): “From Signals to Chromatin: Regulation of germ layer formation by Tbx transcription factors”
  12:25 – 12:50 Alex SCHIER (Basel): “Broad versus deep views of development: insights from zebrafish”
  12:50 – 12:55 Flash Talk 1 Qiutan YANG (Basel): “Cell fate coordinates mechano-osmotic forces in intestinal crypt formation”
  12:55 – 13:00 Flash Talk 2 Wenjing QI (Freiburg): “A secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. Elegans”

 

13:00 - 13:30               General Discussion

13:30                             FAREWELL REMARKS (CIBSS Speaker Team) and END OF MEETING