CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Ca2+-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range

Constantin CE, Schmidt B, Schwarz Y, Harada H, Kollewe A, Müller CS, Henrich S, Gaal B, Kulik A, Bruns D, Schulte U, Rieger H, Fakler B.

Nat Commun. 2025; doi: 10.1038/s41467-025-62735-5

Using Ca2+-activated K+ channels as native and fast sensors for intracellular Ca2+ we show that PMCA-NPTN complexes operate in the kiloHertz range (equivalent to several thousand cycles per second) thus providing the fast Ca2+-clearance fundamental for rapid signal transduction in the brain.