Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli

Popp C, Moser P, Schwoerbel A, Liu X, Freitag J, Sarmah P, Prucker I, Zscherp R, Wang X, Klahn P, Koch HG, Bange G, Jessen HJ.

Angew Chem Int Ed Engl. 2026; doi: 10.1002/anie.202523307

We develop caged magic spot nucleotides and deliver them into living bacteria using cyclodextrin transporters. Photochemical release enables control over MSN concentration inside bacteria.