CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Gastrin for the treatment of acute graft-versus-host disease of the stomach

Gawron J, Czech M, Rückert T, Holzmüller V, Andreev G, Burk AC, Hartmann A, Chatterjee S, Andrieux G, Marquard FE, Baur AS, Stell AV, Krausz M, Braun LM, Osswald N, Melchinger W, Wertheimer T, Proano-Vasco AI, Maas-Bauer K, Schmitt-Graeff A, Boerries M, Köhler N, Ayuk FA, Schell C, Quante M, Zeiser R.

Blood. 2026; doi: 10.1182/blood.2025031080. Online ahead of print.

We observed that aGVHD caused a loss of gastrin-producing G-cells and parietal cells (PCs) and an increase of pH in the stomach, while allogeneic T cells infiltrated the stomach wall. Pentagastrin treatment of aGVHD mice rescued the loss of PCs and normalized the pH in the stomach.