CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle

Bremer J, Nagel J, Zschüntzsch J, Zajt KK, Palaz T, Blank T, Ikis A, Fischer LA, Sensmeyer ASM, Wiechers L, Reichelt JJ, Hofmann KP, Wolf MJ, Leuchtenberger C, Tripathi P, Einer C, Zischka H, Rothermel U, Eck AL, Reimann R, Kana V, Rushing E, Aguzzi A, Prinz M, Liebetanz D, Odoardi F, Kuo CC, Weis J, Kraft F, Schmidt J, Heikenwälder M.

Brain. 2025; doi: 10.1093/brain/awaf260.

In summary, these data provide evidence that inflammation and autophagy disruption play a synergistic role in the development of IBM-like muscular pathology.