CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies

Rassner M, Müller TA, Crossley KA, Andrieux G, Schaberg S, Endres C, Jakob L, Poggio T, Köhler N, Kolter J, Müller-Newen G, Schönberger K, Cabezas-Wallscheid N, Gonzalez-Menendez I, Quintanilla-Martinez L, Zwick M, Ashok D, Hartmann TN, Groß O, Gorka O, Follo M, Illert AL, Boerries M, Zeiser R, Duyster J.

Signal Transduct Target Ther. 2025; doi: 10.1038/s41392-025-02491-6.

We found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M (OSM), which triggers disease progression and immunosuppression in MPN.