Secretion-based production of prolyl-hydroxylated human type III collagen in scalable Physcomitrella photobioreactors

Bohlender LL, Parsons J, Mitgau A, Hoernstein SNW, Grigolon G, Henes B, Decker EL, Reski R.

Plant Cell Rep. 2026; doi: 10.1007/s00299-026-03727-7.

In this study, a recombinant prolyl-hydroxylated human type III collagen polypeptide was produced in scalable moss photobioreactors, providing a sustainable, vegan alternative to animal-derived collagens for cosmetic applications.