CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Principal Investigators

Prof. Dr. Dr. Bertram Bengsch

Prof. Dr. Dr. Bertram Bengsch

Kontakt

Prof. Dr. Dr. Bertram Bengsch
Department of Internal Medicine II - Gastroenterology, Hepatology, Endocrinology and Infectionology
University Medical Center, Faculty of Medicine

T +49 761 270 35860
bertram.bengsch(at)uniklinik-freiburg.de

Weitere Informationen

10 selected publications

  • Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns.
    Bengsch B, Ohtani T, Herati RS, Bovenschen N, Chang KM, Wherry EJ. (2018).
    J Immunol Methods. 453:3-10.
  • Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells.
    Herati RS, Muselman A, Vella L, Bengsch B, Parkhouse K, Del Alcazar D, Kotzin J, Doyle SA, Tebas P, Hensley SE, Su LF, Schmader KE, Wherry EJ. (2017).
    Sci Immunology 2, pii: eaag2152.
  • T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.
    Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ. (2017).
    Nature 545, 60-65.
  • Bioenergetic insufficiencies due to metabolic alterations are an early driver of CD8 T cell exhaustion.
    Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. (2016).
    Immunity 45, 358-373.
  • Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+ coproducing CD4+ T cells in active inflammatory bowel disease.
    Globig AM, Hennecke N, Martin B, Seidl M, Ruf G, Hasselblatt P, Thimme R, Bengsch B. (2014).
    Inflamm Bowel Dis. 20, 2321-2329.
  • Restoration of HBV-specific CD8+ T-cell function by PD-1 blockade in inactive carrier patients is linked to T-cell differentiation.
    Bengsch B, Martin B, Thimme R. (2014).
    J Hepatology 61, 1212-1219.
  • Factors that determine the antiviral efficacy of HCV-specific CD8+ T cells ex vivo.
    Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R. (2013)
    Gastroenterology 144, 426-436.
  • Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).
    Bengsch B*, Seigel B*, Flecken T, Wolanski J, Blum HE, Thimme R. (2012).
    J Immunology 188, 5438-5447.
  • Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential.
    Jo J*, Bengsch B*, Seigel B, Rau SJ, Schmidt J, Bisse E, Aichele P, Aichele U, Joeckel L, Royer C, Sá Ferreira K, Borner C, Baumert TF, Blum HE, Lohmann V, Fischer R, Thimme R. (2012).
    J Hepatology 57, 9-16.
  • Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.
    Bengsch B*, Seigel B*, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. (2010).
    PLoS Pathogens 6, e1000947.

* contributed equally