CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Associate Investigators

Dr. Franziska Schneider-Warme

Emmy Noether Group Leader

Dr. Franziska Schneider-Warme

Kontakt

Dr. Franziska Schneider-Warme
Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, and Faculty of Medicine, University of Freiburg

T +49 761 270 63954
Franziska.schneider.uhz(at)uniklinik-freiburg.de

Weitere Informationen

We are interested in understanding heterocellular biophysical interactions between key cell types in the heart, both in healthy myocardium and following cardiac remodeling post-injury. More specifically, we study the functional relevance of non-myocytes for cardiac electrophysiology. To this end, we combine multi-scale structural and functional imaging, electrophysiological measurements, optogenetic approaches and computational modelling. We also develop novel optogenetic tools for modulating the activity of excitable cells, such as our recently established light-gated K+ channel system PAC/K.  

 

Keywords

optogenetics; heterocellular interactions; electrophysiology; cardiac non-myocytes; light-gated K+ channel

10 selected publications:

  • Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels.
    Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F.
    Cardiovasc Res. 2021/doi: 10.1093/cvr/cvab126 (online ahead of print)
  • Cardiac Electrophysiological Effects of Light-Activated Chloride Channels.
    Kopton RA, Baillie JS, Rafferty SA, Moss R, Zgierski-Johnston CM, Prykhozhij SV, Stoyek MR, Smith F, Kohl P, Quinn TA, Schneider-Warme F (2018).
    Front Physiol 9:1806
  • Potassium channel-based optogenetic silencing.
    Bernal Sierra YA*, Rost BR*, Pofahl M*, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R, Schmitz D (2018).
    Nat Commun 9(1):4611
  • Optogenetic Tools for Subcellular Applications in Neuroscience.
    Rost BR*, Schneider-Warme F*, Schmitz D, Hegemann P (2017).
    Neuron 96(3):572-603
  • Optogenetic acidification of synaptic vesicles and lysosomes.
    Rost BR*, Schneider F*, Grauel MK, Wozny C, Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C (2015).
    Nat Neurosci 18(12):1845-1852
  • Biophysics of Channelrhodopsin.
    Schneider F, Grimm C, Hegemann P (2015).
    Annu Rev Biophys 44:167-86
  • Conversion of channelrhodopsin into a light-gated chloride channel.
    Wietek J*, Wiegert JS*, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P (2014).
    Science 344(6182):409-12
  • Ion selectivity and competition in channelrhodopsins.
    Schneider F, Gradmann D, Hegemann P (2013).
    Biophys J 105(1):91-100
  • Color-tuned channelrhodopsins for multiwavelength optogenetics.
    Prigge M*, Schneider F*, Tsunoda SP, Shilyansky C, Wietek J, Deisseroth K, Hegemann P (2012).
    J Biol Chem 287(38):31804-12
  • Neocortical excitation/inhibition balance in information processing and social dysfunction.
    Yizhar O*, Fenno LE*, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K (2011).
    Nature 477(7363):171-8
    * equal contribution