Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Dr. Giorgos Pyrowolakis

Dr. Giorgos Pyrowolakis

ZBSA Centre for Biological Systems Analysis
University of Freiburg

+49 761 203 8459

CIBSS Research Project:


10 selected publications:

  • AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis.
    Tracy Cai X, Li H, Safyan A, Gawlik J, Pyrowolakis G, Jasper H (2019).
    Nat Commun. 10(1):2988
  • Sequence environment of BMP-dependent activating elements controls transcriptional responses to Dpp signaling in Drosophila.
    Chayengia M, Veikkolainen V, Jevtic M, Pyrowolakis G (2019).
    Development. 146(11)
  • Gene regulation during Drosophila eggshell patterning.
    Pyrowolakis G, Veikkolainen V, Yakoby N, Shvartsman SY. (2017)
    Proc Natl Acad Sci USA, 114 (23), 5808-1.
  • Pentagone fine-tunes glypicans to regulate multiple signaling pathways.
    Norman M, Vuilleumier R, Springhorn A, Gawlik J, Pyrowolakis G (2016).
    Elife, e13301.
  • The decapentaplegic/TGF-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in Drosophila embryos.
    Beira JV, Springhorn A, Pyrowolakis G, Vincent JP (2014).
    Dev Cell. 31(2) 240-47.
  • Transcriptional Interpretation of the EGFR signaling gradient.
    Fuchs A, Cheung LS, Charbonnier E, Shvartsman SY*, Pyrowolakis G* (2012).
    Proc Natl Acad Sci USA. 109, 1572-77. *shared senior authorship
  • Expansion-repression mechanism for scaling the Dpp activation gradient in Drosophila wing imaginal discs.
    Ben-Zvi D, Pyrowolakis G, Barkai N, Shilo BZ (2011).
    Curr Biol. 21, 1391-96.
  • Control of Dpp morphogen distribution by a secreted feedback regulator.
    Vuilleumier R, Springhorn A, Patterson L, Koidl S, Hammerschmidt M, Affolter M, Pyrowolakis G (2010).
    Nat Cell Biol. 12, 611-617.
  • A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.
    Pyrowolakis G, Hartmann B, Muller B, Basler K, Affolter M (2004).
    Dev Cell, 7, 229-240.
  • Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.
    Müller B*, Hartmann B*, Pyrowolakis G*, Affolter M, Basler K (2003).
    Cell 113, 221-33. *equal contribution