Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Prof. Dr. Henning Jessen

Prof. Dr. Henning Jessen

Institute of Organic Chemistry (Faculty of Chemistry and Pharmacy)
University of Freiburg

+49 761 203 6041

CIBSS Research Project:


10 selected publications:

  • Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line
    Hauke ,S Dutta AK, Eisenbeis V, Bezold D, Bittner T, Wittwer C, Thakor D, Pavlovic I, Schultz C*, Jessen HJ*
    Chem Sci. 10, 2687-2692.
  • Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis.
    Haas TM, Ebensperger P, Eisenbeis VB, Nopper C, Dürr T, Jork N, Steck N, Jessen-Trefzer C, Jessen HJ (2019).
    Chem Commun (Camb). 55(37):5339-5342
  • A Phosphoramidite analogue of cyclotriphosphate enables iterative polyphosphorylations.
    Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender PA, Bhandari R, Jessen HJ (2019).
    Angew Chem Int Ed Engl. 58(12):3928-3933.
  • Screening a protein array with synthetic biotinylated inorganic polyphosphate to define the human PolyP-ome.
    Azevedo C, Singh J, Steck N, Hofer A, Ruiz FA, Singh T, Jessen HJ, Saiardi A (2018).
    ACS Chem Biol. 13(8):1958-1963.
  • A 1-phytase type III effector interferes with plant hormone signaling.
    Blüher D, Laha D, Thieme S, Hofer A, Eschen-Lippold L, Masch A, Balcke G, Pavlovic I, Nagel O, Schonsky A, Hinkelmann R, Wörner J, Parvin N, Greiner R, Weber S, Tissier A, Schutkowski M, Lee J, Jessen HJ*, Schaaf G*, Bonas U* (2017).
    Nat Commun. 2017;8(1):2159.
  • Inositol pyrophosphate specificity of the SPX-dependent polyphosphate polymerase VTC.
    Gerasimaite R, Pavlovic I, Capolicchio S, Hofer A, Schmidt A, Jessen HJ*, Mayer A* (2017)
    ACS Chem Biol. 12, 648-53.
  • Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.
    Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ (2016).
    Nat Commun. 7, 10622.
  • Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
    Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A (2016).
    Science 352, 986-90.
  • Prometabolites of 5-diphospho-myo-inositol pentakisphosphate.
    Pavlovic I, Thakor DT, Bigler L, Wilson MS, Laha D, Schaaf G, Saiardi A, Jessen HJ (2015).
    Angew Chem Int Ed. 54, 9622-6.
  • Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation.
    Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ (2014).
    Angew Chem Int Ed. 53, 9508-11.