CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells

Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T, Bengsch B, Thimme R, Hofmann M, Neumann-Haefelin C.

Nat Med. 2020 Nov 12. Online ahead of print

Nat Medicine               online article

SARS-CoV-2-specific CD8+ T cells were analyzed before during and after acute resolving SARS-CoV2 infection. We observe rapid induction, prolonged contraction and emergence of heterogeneous and functionally competent cross-reactive and induced memory CD8+ T cell responses.