CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Towards the molecular architecture of the peroxisomal receptor docking complex.

Lill P, Hansen T, Wendscheck D, Klink BU, Jeziorek T, Vismpas D, Miehling J, Bender J, Schummer A, Drepper F, Girzalsky W, Warscheid B, Erdmann R, Gatsogiannis C.

Proc Natl Acad Sci U S A. 2020  doi: 10.1073/pnas.2009502117

Proc Natl Acad Sci U S A.          online article

We present the first structure of the peroxisomal docking complex Pex14p/Pex17p revealing its subunit organization and a model of its function. The study features an integrative structural biology approach combining cryo-electron microscopy, chemical crosslinking and native mass spectrometry.