CIBSS - Centre for integrative Biological Signalling Studies CIBSS

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone.

Sigloch C, Spitz D, Driever W.

Development. 2023; doi: 10.1242/dev.201301.

Delta/Notch signaling and HES/Her transcription factors balance neural stem cell (NSC) maintenance with the generation of neurons. We analyzed Notch-dependent and -independent Her activities genetically, and present a regulatory network model that explains aspects of the robustness of NSCs.