Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP3-4 kinase activity

Desmarini D, Liu G, Jessen H, Bowring B, Connolly A, Crossett B, Djordjevic JT.

mBio. 2024; doi: 10.1128/mbio.00608-24

 

Inositolphosphate kinases are important in maintaining virulence of fungi. Here, we demonstrate the importance of Arg1 in virulence in cryptococcus neoformans and candida albicans and that it is conveyed by its IP kinase activity, not any lipid kinase activity.