Distinct Argonaute2-associated small RNA profiles in microglia and neurons drive cell-specific responses in a mouse model of temporal lobe epilepsy

Villalba-Benito L, Mathoux J, Auer T, Narasimhan K, Colbert R, Reynolds JP, Brindley E, Batool A, Hill TDM, Diviney M, VenØ MT, Prinz M, Connolly NMC, Dooley D, Henshall DC, Brennan GP.

Neurobiol Dis. 2026; doi: 10.1016/j.nbd.2026.107284

Our data reveals selective loading and incorporation of miRNAs into Ago2/RISC complexes, independent of overall abundance, in a cell- and disease-stage specific manner as well as differential processing of tRNAs in microglia compared to neurons.