CIBSS - Centre for integrative Biological Signalling Studies CIBSS

FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia

Zwick M, Zinkel B, Spohr C, Rückert T, Halbach S, Shoumariyeh K, Scheid J, Baur AS, Braun LM, Angel M, Michaeli E, Todkar A, Nelde A, Märklin M, Holzmayer SJ, Dicks S, Boerries M, Duquesne S, Schlaak AE, Otto-Mora P, Bengsch B, Schiff M, Kissel S, Selle M, Follo M, Altmann H, Kunadt D, Illert AL, Walz JS, Walz G, Duyster J, Schetelig J, Brummer T, Zeiser R, Köhler N.

Cancer Research. 2025, https://doi.org/10.1158/0008-5472.CAN-25-0349

We found that FLT3-ITD stabilizes CMTM6 at the protein level, increasing PD-L1 surface expression and immune escape in AML. CMTM6 loss or FLT3 inhibition restored T-cell function and improved outcomes post allo-HCT in different leukemia models.