Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms

Bowden S, Brislinger-Engelhardt MM, Hansen M, Andricek A, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P.

PLoS Biol. 2026; doi: 10.1371/journal.pbio.3003583

We investigated the functions of Foxi1 in Xenopus embryonic mucociliary epidermis development and found a novel function in the generation of Notch-ligand expressing mucociliary multipotent progenitors (MPPs).