CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation

Kim H, Schneider M, Raach Y, Karypidis P, Roux J, Perdikaris G, Holdermann S, Kulsvehagen L, Lecourt AC, Narr K, Sankowski R, Diebold M, Bartoszek-Kandler E, Kapfhammer JP, Zimmer G, Pröbstel AK, Prinz M, Kappos L, Sanderson NSR, Derfuss T.

Cell. 2026; doi: 10.1016/j.cell.2025.12.031.

Myelin-reactive B cells were identified in the healthy human B cell repertoire, and expression of LMP1 was observed in the brains of a subset of MS patients.