27 May 2024

Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms

Nital Sumaria, Gina J. Fiala, Daniel Inácio, Marta Curado-Avelar, Ana Cachucho, Rúben Pinheiro, Robert Wiesheu, Shunsuke Kimura, Lucien Courtois, Birte Blankenhaus, Julie Darrigues, Tobias Suske, Afonso R. M. Almeida, Susana Minguet, Vahid Asnafi, Ludovic Lhermitte, Charles G. Mullighan, Seth B. Coffelt, Richard Moriggl, João T. Barata, Daniel J. Pennington & Bruno Silva-Santos.
Nature Immunology volume 25, 2024, https://doi.org/10.1038/s41590-024-01855-4

We demonstrate the existence of γδ T cells expressing CD8αβ. These cells contribute to rapid IFN-γ responses in early life and their development is guided by low TCR signaling, IL-4, and IL-7. Overactive IL-7R-STAT5B signaling contributes to γδ T cell transformation.