CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells

Maas-Bauer K, Köhler N, Stell AV, Zwick M, Acharya S, Rensing-Ehl A, König C, Kroll J, Baker J, Koßmann S, Pradier A, Wang S, Docquier M, Lewis DB, Negrin RS, Simonetta F.

J Leukoc Biol. 2023; doi: 10.1093/jleuko/qiad113.

In this collaborative project we studied the transcriptome of human thymic invariant natural killer (iNKT) cells using scRNA-seq. Our data suggest the existence of different maturation stages of human thymic iNKT cells and provide evidence for sublineage commitment of iNKT cells in the human thymus.