Towards Dissecting the Mechanism of Protein Phosphatase-1 Inhibition by Its C-Terminal Phosphorylation

Salvi F, Hoermann B, Del Pino García J, Fontanillo M, Derua R, Beullens M, Bollen M, Barabas O, Köhn M.

Chembiochem. 2021; doi: 10.1002/cbic.202000669

PP1 is a ubiquitous phosphatase that is involved in multiple cellular processes. Here, we use PP1 variants created by mutations and protein semisynthesis to decipher the mechanism of its regulation through its C-terminal phosphorylation.