CIBSS - Centre for integrative Biological Signalling Studies CIBSS

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CIBSS Publications

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Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants

Wegehaupt O, Borisov O, Sieni E, Oyen F, Mann J, Coniglio ML, Chinnici A PhD, Pegoraro F, Beneforti L, Gilmour KC, Moshous D, de Saint Basile G, Zhang W, Marsh RA, De Fusco C, Wustrau K, Timeus F, Micalizzi C, Gunsilius E, Hosking L, Choo S, Ghosh S, Köttgen A, Lehmberg K, Ehl S.

Blood. 2025 Mar 16; doi: 10.1182/blood.2024027954. Online ahead of print.

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A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation

Forster PM, Jakob MO, Yusuf D, Bubeck M, Limberger H, Luo Y, Thieme P, Polici A, Sterczyk N, Boulekou S, Bartel L, Cosovanu C, Witkowski M, González-Acera M, Kühl AA, Weidinger C; TRR241 IBDome Consortium; Backofen R, Hegazy AN, Patankar JV, Klose CSN.

Neuron. 2025; doi: 10.1016/j.neuron.2025.02.018. Online ahead of print.

Fight to survive: Marchantia synthesizes newly identified metabolites in response to wounding

Pitsili E, Maric A.

Plant Physiol. 2025 Mar 4. doi: 10.1093/plphys/kiaf066. Online ahead of print.

Comparative analysis using a chromosome-scale genome assembly for Funaria hygrometrica suggests greater collinearity in mosses than in seed plants

Kirbis A, Rahmatpour N, Dong S, Yu J, Waser L, Huang H, van Gessel N, Waller M, Reski R, Lang D, Rensing S A, Temsch Eva M, Wegrzyn J L, Goffinet B, Liu Y, Szövényi P.

Commun Biol. 2025; doi: 10.1038/s42003-025-07749-x.

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Epigenetic control of cell identities from epiblast to gastrulation

Schüle K M, Probst S.

FEBS J. 2025 Feb 22. doi: 10.1111/febs.70024. Online ahead of print.

Pumilio differentially binds to mRNA 3' UTR isoforms to regulate localization of synaptic proteins

Grzejda D, Hess A, Rezansoff A, Gorey S, Carrasco J, Alfonso-Gonzalez C, Tsagkris S, Neuhaus L, Shi M, Ozbulut H C, Vögtle F-N, Vlachos A, Hilgers V.

EMBO Rep. 2025 Feb 21. doi: 10.1038/s44319-025-00401-z. Online ahead of print.

Metabolite-Responsive Control of Transcription by Phase Separation-Based Synthetic Organelles

Jerez-Longres C, Weber W.

ACS Synth Biol. 2025 Feb 15. doi: 10.1021/acssynbio.4c00633. Online ahead of print.

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis

Wortel C M, van de Wetering R, Stork E M, Kissel T, Reijm S, van der Woude D, van Schie K A, Trouw L A, Teng Y, Rutgers A, Heeringa P, Voll R E , Rizzi M, Venhoff N, Toes R, Scherer H U.

Nat Commun. 2025 Feb 12. doi: 10.1038/s41467-025-56786-x.

The intestinal microbiome and metabolome discern disease severity in cytotoxic T-lymphocyte-associated protein 4 deficiency

Chandrasekaran P, Krausz M, Han Y, Mitsuiki N, Gabrysch A, Nöltner C, Proietti M, Heller T, Grou C, Calderon V, Subramanian P, Jones D R, Siu Y, Deming C, Conlan S, Holland S M, Segre J A, Uzel G, Grimbacher B, Falcone E L.

Microbiome. 2025 Feb 11. doi: 10.1186/s40168-025-02028-7.

Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

Braun L M, Giesler S, Andrieux G, Riemer R, Talvard-Balland N, Duquesne S, Rückert T, Unger S, Kreutmair S, Zwick M, Follo M, Hartmann A, Osswald N, Melchinger W, Chapman S, Hutchinson J A, Haferkamp S, Torster L, Kött J, Gebhardt C, Hellwig D, Karantzelis N, Wallrabenstein T, Lowinus T, Yücel M, Brehm N, Rawluk J, Pfeifer D, Bronsert P, Rogg M, Mattern S, Heikenwälder M, Fusco S, Malek N P, Singer S, Schmitt-Graeff A, Ceteci F, Greten F R, Blazar B R, Boerries M, Köhler N, Duyster J, Ihorst G, Lassmann S, Keye P, Minguet S, Schadendorf D, Ugurel S, Rafei-Shamsabadi D, Thimme R, Hasselblatt P, Bengsch B, Schell C, Pearce E L, Meiss F, Becher B, Funke-Lorenz C, Placke J-M, Apostolova P, Zeiser R.

Cancer Cell. 2025 Feb 10. doi: 10.1016/j.ccell.2025.01.004.

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