Cluster of Excellence, University of Freiburg

CIBSS-B – Metabolic and Multicellular Signalling

CIBSS forges new research directions addressing the mechanisms by which signalling processes are integrated with metabolic and environmental cues. This research elucidates how signalling, cellular metabolism and development are reciprocally regulated, and how metabolism shapes cellular function. CIBSS studies how signals are propagated from the molecular and cellular scales to the tissue and organismal levels in order to achieve multicellular organization and orchestrate development and tissue repair.



Anne Classen

Julia Jellusova

Erika Pearce

Gerd Walz



Funded projects within CIBSS Area B

 • Signal interpretation controlling diverging specification programs during gastrulation in mouse and in ES cell differentiation (Sebastian Arnold)

 • Stress-granule dependent regulation of mitochondrial activity controls non-cell-autonomous stem cell tumorigenesis (Ralf Baumeister)

 • Integration of T cell receptor and co-regulatory signalling with metabolic signals in T cell exhaustion (Bertram Bengsch)

 • The role of Gprc5c in regulating hematopoietic stem cells (Nina Cabezas-Wallscheid)

 • Early transcriptional and signalling responses to tissue injury (Anne-Katrin Classen)

 • Spatiotemporal signal integration in control of the neural stem cell niche and progenitor plasticity (Wolfgang Driever)

 • Human immunodeficiency as a window to explore the integration of signalling and metabolic functions of STAT3 (Stephan Ehl)

 • Small molecule discovery for metabolic signalling research: from immunomodulators to cancer therapeutics (Olaf Groß)

 • Revealing cellular crosstalk in the liver at single-cell resolution (Dominic Grün)

 • The role of p62/SQSTM1 in integrating metabolic and signalling cues in B cells (Julia Jellusova)

 • Macrophage derived cytokine signals as key regulators of metabolic tissue homeostasis and function in adult Drosophila melanogaster (Karin Kierdorf)

 • Spatiotemporal control of Ca2+ signalling and metabolism during left-right patterning and tubular morphogenesis in health and disease (Michael Köttgen)

 • 3D nanoscopy and nanomechanics linking molecular signals to biophysical phenotype (Peter Kohl)

 • The role of SNO-GAPDH in controlling inflammatory gene expression in activated macrophages (Edward Pearce, Erika Pearce)

 • Intrinsic and extrinsic factors driving the development and function of tissue macrophages in the CNS: from yolk sac to disease (Marco Prinz)

 • TGFß/BMP signalling in space, time and function (Giorgos Pyrowolakis)

 • Integration of notch signalling over time and space controls cell fate decisions in vertebrate mucociliary cells (Peter Walentek)

 • The role of Activation Transcription Factor 3 (ATF3) in coordinating cell migration and regeneration (Gerd Walz)