Cluster of Excellence, University of Freiburg

CIBSS-C – Towards Discovery-Driven Innovation

The new synthetic biological and chemical tools developed in CIBSS will enable dynamic modulation of signalling processes and control of biological function. These control-of-function technologies are applied in all areas of CIBSS research in order to analyse how molecular signalling events at distinct locations and point in time are translated across biological scales into changes in fate and function of cells and tissues. This research will contribute to an integrative understanding of biological signalling processes and will propel the discoveries and technologies resulting from the CIBSS Research Programme towards innovation in medicine and plant sciences.



Henning Jessen

Maja Köhn

Thomas Ott

Wolfgang Schamel



Funded projects within Research Area C

 • Studying NF-κB signalling in health and disease combining optogenetics and mathematical modelling (Bodo Grimbacher and Barbara DiVentura)

 • Light-regulation of the root nodule symbiosis and nitrogen fixation by a mobile shoot-to-root signal (Andreas Hiltbrunner)

 • Photocaged inositol pyrophosphates and their effects on calcium signalling in the imaginal disc (Henning Jessen)

 • Development of peptide mimics for the spatio-temporal control and study of phosphatases SHP1 and SHP2 and the kinase LCK in immune receptor signaling (Maja Köhn)

 • Aligning dynamic TCR assembly with optimal anti-tumour responses (Susana Minguet)

 • Molecular reconstitution and precision targeting of functional receptor nanoclusters on plasma membranes (Thomas Ott)

 • Control metabolic pathways by optogenetically-regulated AMPK and AKT (Gerald Radziwill)

 • The opto-TCR: impact of the dynamics and nanoscale organisation of TCR assemblies on T cell fate (Wolfgang Schamel)

 • Animal models and chemical tools for precision epigenome editing (Roland Schüle and Manfred Jung)

 • Generally applicable optogenetic strategy for the spatiotemporal control of signalling (Wilfried Weber)

 • Forcing mitochondrial fusion in T cells to enhance tumour elimination (Robert Zeiser)