CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Principal Investigators

Dr. Nina Cabezas-Wallscheid

Dr. Nina Cabezas-Wallscheid

Contact

Dr. Nina Cabezas-Wallscheid
Max Planck Institute of Immunobiology and Epigenetics Freiburg

T +49 761 5108 530
cabezas(at)ie-freiburg.mpg.de

Further Information

The goal of our laboratory is to gain new biological insights on how hematopoietic stem cell dormancy is regulated. Specifically, we aim to elucidate the mechanism by which vitamin A and Gpr signaling maintain the molecular and metabolic state of dormancy. Our future findings will provide unique in-depth insight into the functional signaling networks that regulates hematopoietic stem cell fate and it can be expected that we will provide pioneering therapeutic avenues for nutritional and hematological diseases. To address these biological questions, we are pursuing interdisciplinary projects which include the use of genetic mouse models, primary patient material in combination with state-of-the-art population and single-cell OMICs analysis.

 

Keywords:

Hematopoietic stem cells, leukemic stem cells, diets, cell fate, metabolism, epigenetics, signaling, single-cell, metabolomics, in vivo.



Our ultimate goal is to translate our findings into human disease such as dietary deficiencies and leukemia

10 selected publications:

  • Vitamin C: C-ing a new way to fight leukemia.
    Schönberger K, Cabezas-Wallscheid N (2017).
    Stem Cell. 21, 561-563.
  • Vitamin A/ retinoic acid signaling regulates hematopoietic stem cell dormancy.
    Cabezas-Wallscheid N*,§, Buettner F*, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian M.C, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinik D, Geiger H, Schroeder T, Benes V, Dick TB, Rieger MA, Stegle O, Trumpp A§ (2017).
    Cell. 169, 1-17
    *co-first authors. §corresponding authors.
  • Stem Cells. Potency finds its niches.
    Cabezas-Wallscheid N, Trumpp A (2016).
    Science 351, 126-7.
  • Myc depletion induces a pluripotent dormant State mimicking diapause
    Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A (2016).
    Cell. 164, 668-80.
  • Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.
    Cabezas-Wallscheid N*, Klimmeck D*, Hansson J*, Lipka DB*, Reyes A*, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A (2014).
    Cell Stem Cell. 15(4):507-22.
    *co-first authors
  • Transcriptional landscape, long non-coding RNAs and post transcriptional regulation in hematopoietic stem/progenitor cell commitment.
    Klimmeck D*, Cabezas-Wallscheid N*, Reyes A*, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A (2014).
    Stem Cell Reports. 3, 858-75.
    *co-first authors.
  • Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.
    Lipka DB*, Wang Q*, Cabezas-Wallscheid N*, Klimmeck D*, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C (2014).
    Cell Cycle. 13, 3476-3487.
    *co-first authors
  • Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking Granzyme B.
    Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A. (2014).
    J Exp Med. 211, 769-79.
  • Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.
    Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E (2013).
    EMBO Mol Med. 5, 1804-20.
  • Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression.
    Wörtge S, Eshkind L, Cabezas-Wallscheid N, Lakaye B, Kim J, Heck R, Abassi Y, Diken M, Sprengel R, Bockamp E. (2010).
    BMC Dev Biol. 10, 95