CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Principal Investigators

Prof. Dr. Henning Jessen

Prof. Dr. Henning Jessen


Prof. Dr. Henning Jessen
Institute of Organic Chemistry (Faculty of Chemistry and Pharmacy)
University of Freiburg

T +49 761 203 6041

Further Information

10 selected publications:

  • Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry.
    Qiu D, Wilson MS, Eisenbeis VB, Harmel RK, Riemer E, Haas TM, Wittwer C, Jork N, Gu C, Shears SB, Schaaf G, Kammerer B, Fiedler D, Saiardi A, Jessen HJ (2020).
    Nat Commun. 11(1):6035.
  • Photolysis of Caged Inositol Pyrophosphate InsP8 Directly Modulates Intracellular Ca2+ Oscillations and Controls C2AB Domain Localization.
    Bittner T, Wittwer C, Hauke S, Wohlwend D, Mundinger S, Dutta AK, Bezold D, Dürr T, Friedrich T, Schultz C, Jessen HJ (2020).
    J Am Chem Soc. 142(24):10606-10611
  • Synthesis of Modified Nucleoside Oligophosphates Simplified: Fast, Pure, and Protecting Group Free.
    Singh J, Ripp A, Haas TM, Qiu D, Keller M, Wender PA, Siegel JS, Baldridge KK, Jessen HJ (2019).
    J Am Chem Soc. 141(38):15013-15017.
  • A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative Polyphosphorylations.
    Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender PA, Bhandari R, Jessen HJ (2019).
    Angew Chem Int Ed Engl. 58(12):3928-3933.
  • Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line
    Hauke ,S Dutta AK, Eisenbeis V, Bezold D, Bittner T, Wittwer C, Thakor D, Pavlovic I, Schultz C*, Jessen HJ*
    Chem Sci. 10, 2687-2692.
  • Screening a protein array with synthetic biotinylated inorganic polyphosphate to define the human PolyP-ome.
    Azevedo C, Singh J, Steck N, Hofer A, Ruiz FA, Singh T, Jessen HJ, Saiardi A (2018).
    ACS Chem Biol. 13(8):1958-1963.
  • A 1-phytase type III effector interferes with plant hormone signaling.
    Blüher D, Laha D, Thieme S, Hofer A, Eschen-Lippold L, Masch A, Balcke G, Pavlovic I, Nagel O, Schonsky A, Hinkelmann R, Wörner J, Parvin N, Greiner R, Weber S, Tissier A, Schutkowski M, Lee J, Jessen HJ*, Schaaf G*, Bonas U* (2017).
    Nat Commun. 2017;8(1):2159.
  • Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.
    Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ (2016).
    Nat Commun. 7, 10622.
  • Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
    Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A (2016).
    Science 352, 986-90.
  • Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation.
    Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ (2014).
    Angew Chem Int Ed. 53, 9508-11.