Keywords

Proteomics, high-resolution mass spectrometry, mitochondria, peroxisomes, skeletal muscle, organelle communication, stress response, signaling networks, protein kinases/phosphatases.

T.S. Eliot

"And what you do not know is the only thing you know."

So, following John B. Fenn, we make molecular elephants fly to explore the unknown.

10 selected publications

• Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes.
  Dewar CE, Oeljeklaus S, Mani J, Mühlhäuser WWD, von Känel C, Zimmermann J, Ochsenreiter T, Warscheid B, Schneider A (2022).
  Nat Commun. 13(1):3084.
• Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
  Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B (2021).
  Cell Metab. 33(12):2464-2483.e18.
• Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C.
  Reimann L*, Schwäble AN*, Fricke A, Muehlhaeuser W, Leber Y, Lohanadan K, Puchinger M, Schäuble S, Fässler E Wiese, H, Reichenbach C, Knapp B, Peikert CD, Drepper F, Hahn U, Kreutz C, van der Ven PFM, Radziwill G, Djinović-Carugo K, Fürst DO, Warscheid B (2020).
  Commun Biol, 3:253.
• Mitochondrial protein translocation-associated degradation.
  Mårtensson CU, Priesnitz C, Song J, Ellenrieder L, Doan KN, Boos F, Floerchinger A, Zufall N, Oeljeklaus S, Warscheid B, Becker T (2019).
  Nature. 2019 May;569(7758):679-683.
• Quantitative proteomics identifies zinc-based redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
  Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A*, Warscheid B* (2018).
  Nat Commun 9:324.
  *corresponding
• Definition of a high confidence mitochondrial proteome at quantitative scale.
  Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmeier S, Drepper F, Weill U, Höß P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schütze C, Oeljeklaus S, Pfanner N, Wiedemann N*, Warscheid B* (2017).
  Cell Rep 9:2836-2852.
  *corresponding
• Charting organellar importomes by quantitative mass spectrometry.
  Peikert CD, Mani J, Morgenstern M, Sandro K, Knapp B, Wenger C, Harsman A, Oeljeklaus S, Schneider A*, Warscheid B* (2017).
  Nat Commun 8, 15272.
  *corresponding
• Myofibrillar Z-discs are a protein phosphorylation hot spot with PKCα modulating protein dynamics.
  Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke AL, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PF, Radziwill G, Fürst DO, Warscheid B. (2016)
  Mol Cell Proteomics. 16:346-367.
• Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.
  Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B*, Chacinska A.* (2015)
  Nature. 524(7566):485-8.
  *shared senior authorship
• Characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.
  Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham, HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJA, Warscheid B (2007).
  Mol Cell Proteomics 6(12):2045-57.