Associate Investigators · Investigators

Jun.-Prof. Dr. Priscilla S. Briquez

Jun.-Prof. Dr. Priscilla S. Briquez

Contact

Jun.-Prof. Dr. Priscilla S. Briquez
Department of General and Visceral Surgery, Faculty of Medicine, Medical Center – University of Freiburg

T +49 761 270 77574
priscilla.briquez(at)uniklinik-freiburg.de

Further Information

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Research

Our laboratory is specialized in protein engineering, which we apply to develop novel immunotherapies for cancer, regenerative medicine, and other immune-related diseases. The goal of our research is to innovate effective and safe immunotherapies for clinical use. By doing so, we develop novel immunoengineering tools to address key questions in immunology.

A primary focus in our laboratory is the engineering of immune-signaling molecules (e.g., cytokines) and cell-based therapies (e.g., CAR-T cells) for targeted delivery to inflamed tissues, particularly by modulating their interactions with the extracellular matrix. Another important focus is the engineering of synthetic membrane receptors in living cells and the characterization of their clustering and signaling properties, as a potential new avenue to create next-generation protein and cell-based therapeutics.

Keywords:

Immunoengineering, cancer, regenerative medicine, therapeutic proteins, cell-based therapies.

“At the intersection of immunology and engineering, we push the boundaries in the fight against disease.”

Ten most important publications

  • Membrane-localized neoantigens predict the efficacy of cancer immunotherapy. Goldberger Z, Hauert S, Chang K, Kurtanich T, Alpar AT, Repond G, Wang Y, Gomes S, Krishnakumar R, Siddarth P, Swartz MA, Hubbell JA+, Briquez PS+. Cell Rep Med. 2023 Aug 15;4(8):101145. doi: 10.1016/j.xcrm.2023.101145. Epub 2023 Aug 7. PMID: 37552990; PMCID: PMC10439248.
  • Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity. Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA. Sci Adv. 2022 Oct 7;8(40):eabn3777. doi: 10.1126/sciadv.abn3777. Epub 2022 Oct 7. PMID: 36206332; PMCID: PMC9544317.
  • Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine. Liu J, Solanki A, White MJV, Hubbell JA+, Briquez PS+. NPJ Regen Med. 2022 Jun 30;7(1):34. doi: 10.1038/s41536-022-00230-x. PMID: 35773290; PMCID: PMC9246914.
  • Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant. Biomaterials. Gray LT*, Raczy MM*, Briquez PS*, Marchell TM*, Alpar AT, […], Swartz MA+, Hubbell JA+.  2021 Nov;278:121159. doi: 10.1016/j.biomaterials.2021.121159. PMID: 34634664; PMCID: PMC8482845.
  • Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion. Briquez PS+, Tsai HM, Watkins EA, Hubbell JA+. Sci Adv. 2021 Jun 11;7(24):eabh4302. doi: 10.1126/sciadv.abh4302. PMID: 34117071; PMCID: PMC8195475.
  • Engineering Targeting Materials for Therapeutic Cancer Vaccines. Front Bioeng Biotechnol. Briquez PS*, Hauert S*, de Titta A*, Gray LT, Alpar AT, Swartz MA, Hubbell JA+. 2020 Feb 11;8:19. doi: 10.3389/fbioe.2020.00019. PMID: 32117911; PMCID: PMC7026271.
  • Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Ishihara J, Ishihara A, Fukunaga K, Sasaki K, White MJV, Briquez PS, Hubbell JA. Nat Commun. 2018 Jun 4;9(1):2163. doi: 10.1038/s41467-018-04525-w. PMID: 29867149; PMCID: PMC5986797.
  • Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials. Briquez PS*, Lorentz KM*, Larsson HM, Frey P, Hubbell JA+. Biomaterials. 2017 Aug;135:1-9. doi: 10.1016/j.biomaterials.2017.04.048. PMID: 28477492; PMCID: PMC5702589.
  • Design principles for therapeutic angiogenic materials. Briquez PS*, Clegg LE*, Martino MM, Mac Gabhann F+, Hubbell JA+. Nat Rev Mater. 2016 Jan; 1, 15006.doi: 10.1038/natrevmats.2015.6
  • Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Martino MM*, Briquez PS*, Güç E, Tortelli F, Kilarski WW, Metzger S, Rice JJ, Kuhn GA, Müller R, Swartz MA, Hubbell JA+.  Science. 2014 Feb 21;343(6173):885-8. doi: 10.1126/science.1247663. PMID: 24558160.

( *first author(s), + Corresponding author(s))