Research Project:

Our research is driven by a profound interest in the pathogenesis of heart diseases. We seek to gain insight into the mechanisms responsible for patho-phenotypes by investigating the electrical dyssynchronies caused by mechanical dysfunction. Our approach involves a transdisciplinary collaboration with various groups within CIBSS to understand the interaction of cardiac structure and function in the generation and maintenance of arrhythmias.

Keywords

Computational simulations, cardiac disease, mechano-electric coupling, single cell

 10 selected publications:

• Passive Myocardial Mechanical Properties: Meaning, Measurement, Models; Emig R, Zgierski-Johnston CM, Timmermann V, Taberner AJ, Nash MP, Kohl P, and Peyronnet R, 2021 Biophysical Reviews: 1-24; doi:10.1007/s12551-021-00838-1.
• Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Multi-Scale Computational Model of Coupled Myocytes; Timmermann V and McCulloch AD, 2020 Frontiers in Physiology 11: 1573; doi:10.3389/fphys.2020.519951.
• Arrhythmogenic Current Generation by Myofilament-Triggered Ca2+ Release and Sarcomere Heterogeneity; Timmermann V, Edwards AG, Wall ST, Sundnes J, and McCulloch AD
• An Integrative Appraisal of Mechano-Electric Feedback Mechanisms in the Heart; Timmermann V, Dejgaard LA, Haugaa KH, Edwards AG, Sundnes J, McCulloch AD, and Wall ST, 2019 Progress in Biophysics and Molecular Biology 130: 404-417; doi:10.1016/j.pbiomolbio.2017.08.008.
• An In-Silico Study on Integrated Mechanisms of Mechano-Electric Feedback in Ischemic Arrhythmia; Timmermann V, Sundnes J, Lawen T, Baumeister PA, Quinn TA, McCulloch AD, and Edwards AG; 2023 doi:10.48550/arXiv.2312.06535.
• Quaternion-Aligned Electroanatomical Models of the Murine Atria from Standard-Output Functional and Structural Imaging; Tumlinson G, Chleilat E, Madl J, Kohl P, and Timmermann V; 2023 doi:10.48550/arXiv.2312.02922.