CIBSS Launchpad Funds Recipients 2021

Dr. Sascha Yousefi


Dr. Sascha Yousefi


Dr. Sascha Yousefi
Department of Immunology (Faculty of Biology),
University of Freiburg

T +49 761 203 67513

Further Information

10 selected publications:

  • Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors.
    Hörner M, Jerez-Longres C, Hudek A, Hook S, Yousefi OS, Schamel WWA, Hörner C, Zurbriggen MD, Ye H, Wagner HJ, Weber W, 2021.
    Sci Adv 7(25):eabf0797.
  • Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function.
    Hartl FA, Beck-García E, Woessner NM, Flachsmann LJ, Velasco Cardenas RMH, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WWA and Minguet S (2020).
    Nat Immunol. 21:902. 2020.
  • Optogenetic tuning of ligand binding to the human T cell receptor using the opto-ligand-TCR system.
    Yousefi OS, Hörner M, Wess M, Idstein V, Weber W and Schamel WWA (2020).
    Bio-protocol, 10(05):e3540
  • Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor.
    Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, and Schamel WWA (2019).
    eLife, 8:301
  • Light-controlled affinity purification of protein complexes exemplified by the resting ZAP70 interactome.
    Hörner* M, Eble* J, Yousefi* OS, Schwarz* J, Warscheid B, Weber* W, and Schamel* WWA (2019).
    Front Immunol, 10:637.
  • Optogenetic control of integrin-matrix interaction.
    Baaske J, Mühlhäuser WWD, Yousefi OS, Zanner S, Radziwill G, Hörner M, Schamel WWA, Weber W.
    Commun Biol. 2:15.
  • Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.
    Keller* B, Zaidman* I, Yousefi* OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel* WWA, Elpeleg* O, Warnatz* K, and Stepensky* P (2016).
    J Exp Med. 213(7):1185–1199
  • A cholesterol-based allostery model of T cell receptor phosphorylation.
    Swamy* M, Beck-García* K, Beck-García E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnar E, Schulze AK, Blanco R, Borroto A, Martin-Blanco N, Alarcón B, Höfer T, Minguet* S, and Schamel* WWA (2016).
    Immunity, 44(5):1091–1101.
  • The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
    Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, and Schamel WWA (2014). Cell Reports, 7(5):1704–1715.
  • The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions.
    Yousefi OS, Wilhelm T, Maschke-Neuß K, Kuhny M, Martin C, Molderings GJ, Kratz F, Hildenbrand B, Huber M (2013).
    Cell Communincation and Signaling, 11(1):13,

* first or last authors contributed equally