Research
- Signaling via membrane micro-domains formed by small membrane proteins
- The importance of small molecules for short- and long-term signaling memory
Metabolite sensing is a fundamental biological process, and the perception of dynamic changes in the extracellular environment is of paramount importance for the survival of organisms. This applies in particular to single cell organisms such as bacteria, which execute sophisticated and rapid signaling strategies in response to intracellular and extracellular cues. In our group, we are exploring the impact of these signaling strategies on the entire proteostasis network that controls protein production, folding, trafficking and degradation. We are particularly interested in the role of membrane micro-domains and small signaling molecules in bacterial adaptation.
Keywords
Bacterial adaptation, translational control, antimicrobial peptides, alarmones, stress response.
“Our goal is to explore universally conserved strategies of signal perception and integration.”