CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Associate Investigators

Jun. Prof. Dr. Katrin Kierdorf

Jun. Prof. Dr. Katrin Kierdorf

Contact

Jun. Prof. Dr. Katrin Kierdorf
Institute of Neuropathology
University Medical Center, Faculty of Medicine

T +49 761 270 50780
katrin.kierdorf(at)uniklinik-freiburg.de

Further Information

Our research focuses on different aspects of macrophage development and physiological function. Macrophages are long-lived immune cells which can be found throughout all tissues and in nearly all metazoan organisms. They are building a complex network of resident immune cells throughout the tissues which offers a first line of defense against invading pathogens, but also regulate organ function and tissue homeostasis. Within our work we aim to understand different molecular signaling cascades between the host tissues and their macrophages which guide macrophage development and function. We aim to decipher which signals control the early colonization of host organs with macrophages during development. Furthermore, we aim to identify the signals responsible to control macrophage network assembly within the tissues. Finally we would like to understand how macrophages control tissue homeostasis, especially metabolic homeostasis, and which signals send out by macrophages can integrate and regulate the metabolic signaling machinery within the tissues. To pursue our research goals, our team employs a wide range of techniques and models, including the work with transgenic Drosophila, which offers a fantastic genetic tool box to visualize and modify macrophage function.

 

Keywords:

macrophage, cytokine, metabolism, Drosophila, tissue homeostasis, development

10 selected publications:

  • CNS macrophages and infant infections
    Oschwald A, Petry P, Kierdorf K*, Erny D* (2020).
    *equal contribution
  • Novel Hexb-based tools for studying microglia in the CNS
    Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Meyer-Luehmann M, Knobeloch KP, Prinz M (2020).
    Nat Immunol. 21(7):802-815.
  • Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila
    Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, Gyoergy A, Gross O, Siekhaus D, and Dionne MS (2020)
    Elife 9:e51595
  • Macrophages at CNS interfaces: ontogeny and function in health and disease
    Kierdorf K, Masuda T, Jordão MJC, Prinz M (2019).
    Nat Rev Neurosci 20, 547–562
  • Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
    Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M (2015).
    EMBO J. 35(16):1730-44.
  • Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet.
    Woodcock KJ, Kierdorf K, Pouchelon CA, Vivancos V, Dionne MS, Geissmann F (2015). Immunity. 42(1):133-44.
  • Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias.
    Kierdorf K, Katzmarski N, Haas CA, Prinz M (2013).
    PLoS One. 8(3):e58544.
  • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
    Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M (2013). Nat Neurosci. 2013 Mar;16(3):273-80.
  • A lineage of myeloid cells independent of Myb and hematopoietic stem cells .
    Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, Prinz M, Wu B, Jacobsen SE, Pollard JW, Frampton J, Liu KJ, Geissmann F (2012).
    Science. 336(6077):86-90
  • Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.
    Mildner A*, Schlevogt B*, Kierdorf K*, Böttcher C, Erny D, Kummer MP, Quinn M, Brück W, Bechmann I, Heneka MT, Priller J, Prinz M (2011).
    J Neurosci. 2011 Aug 3;31(31):11159-71. *equally contributed