Principal Investigators

Prof. Dr. Henning Jessen

Prof. Dr. Henning Jessen


Prof. Dr. Henning Jessen

Institute of Organic Chemistry (Faculty of Chemistry and Pharmacy)
University of Freiburg

T +49 761 203 6041

Further Information


10 selected publications:

  • Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast.
    Qin N, Li L, Ji X, Pereira R, Chen Y, Yin S, Li C, Wan X, Qiu D, Jiang J, Luo H, Zhang Y, Dong G, Zhang Y, Shi S, Jessen HJ, Xia J, Chen Y, Larsson C, Tan T, Liu Z, Nielsen J (2023).
    Cell. 186(4):748-763.e15.
  • Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues.
    Qiu D, Gu C, Liu G, Ritter K, Eisenbeis VB, Bittner T, Gruzdev A, Seidel L, Bengsch B, Shears SB, Jessen HJ (2022).
    Chem Sci. 14(3):658-667
  • Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes.
    Haas TM, Laventie BJ, Lagies S, Harter C, Prucker I, Ritz D, Saleem-Batcha R, Qiu D, Hüttel W, Andexer J, Kammerer B, Jenal U, Jessen HJ (2022).
    Angew Chem Int Ed Engl. 61(22):e202201731
  • Stable Isotope Phosphate Labelling of Diverse Metabolites is Enabled by a Family of 18 O-Phosphoramidites.
    Haas TM, Mundinger S, Qiu D, Jork N, Ritter K, Dürr-Mayer T, Ripp A, Saiardi A, Schaaf G, Jessen HJ (2022).
    Angew Chem Int Ed Engl. 61(5):e202112457.
  • The chemistry of branched condensed phosphates.
    Dürr-Mayer T, Qiu D, Eisenbeis VB, Steck N, Häner M, Hofer A, Mayer A, Siegel JS, Baldridge KK, Jessen HJ (2021).
    Nat Commun. 12(1):5368.
  • Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry.
    Qiu D, Wilson MS, Eisenbeis VB, Harmel RK, Riemer E, Haas TM, Wittwer C, Jork N, Gu C, Shears SB, Schaaf G, Kammerer B, Fiedler D, Saiardi A, Jessen HJ (2020).
    Nat Commun. 11(1):6035.
  • Photolysis of Caged Inositol Pyrophosphate InsP8 Directly Modulates Intracellular Ca2+ Oscillations and Controls C2AB Domain Localization.
    Bittner T, Wittwer C, Hauke S, Wohlwend D, Mundinger S, Dutta AK, Bezold D, Dürr T, Friedrich T, Schultz C, Jessen HJ (2020).
    J Am Chem Soc. 142(24):10606-10611
  • Synthesis of Modified Nucleoside Oligophosphates Simplified: Fast, Pure, and Protecting Group Free.
    Singh J, Ripp A, Haas TM, Qiu D, Keller M, Wender PA, Siegel JS, Baldridge KK, Jessen HJ (2019).
    J Am Chem Soc. 141(38):15013-15017.
  • Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.
    Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ (2016).
    Nat Commun. 7, 10622.
  • Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
    Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A (2016).
    Science 352, 986-90.