CIBSS - Centre for integrative Biological Signalling Studies CIBSS

ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice

Srimat Kandadai K, Kotur MB, Dokalis N, Amrein I, Keller CW, Münz C, Wolfer D, Prinz M, Lünemann JD.

Autophagy 2021; doi: 10.1080/15548627.2021.1883880

These data indicate that, basal autophagy, identified to be essential for the survival and function of neuronal cells, is not required to maintain CNS homeostasis if absent in adult microglia and ATG5 expression is dispensable for the development of autoimmune neuroinflammation.