IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Regen T, Isaac S, Amorim A, Núñez NG, et al., ..... Prinz M, Bopp T, Becher B, Ubeda C, Waisman A.

Sci Immunol. 2021; doi: 10.1126/sciimmunol.aaz6563

Our data demonstrated that IL-17A and IL-17F are not encephalitogenic mediators but rather modulators of intestinal homeostasis that indirectly alter CNS-directed autoimmunity.