CIBSS - Centre for integrative Biological Signalling Studies CIBSS

The universally conserved ATPase YchF regulates translation of leaderless mRNA in response to stress conditions

Landwehr V, Milanov M, Angebauer A, Hong J, Jüngert G, Hiersemenzel A, Siebler A, Schmit F, Öztürk Y, Dannenmaier S, Drepper F, Warscheid B, Koch HG

Front Mol Biosci 2021; doi: 10.3389/fmolb.2021.643696

We characterized the universally conserved ATPase YchF in E. coli. Using a combination of biochemical methods and in vivo site directed cross-linking, we demonstrate that YchF associates with the translation initiation factor IF3 and is involved in the regulation of leaderless mRNA translation.