CIBSS - Centre for integrative Biological Signalling Studies CIBSS

A coherent feed-forward loop in the Arabidopsis root stem cell organizer regulates auxin biosynthesis and columella stem cell maintenance

Sharma M, Friedrich T, Oluoch P, Zhang N, Peruzzo F, Jha V, Pi L, Groot EP, Kornet N, Follo M, Aichinger E, Fleck C, Laux T.

Nat Plants. 2024 Oct 11. doi: 10.1038/s41477-024-01810-z. Online ahead of print.

We identify the transcription factor HAN as mediator of WOX5-regulated stem cell maintenance, repressing the differentiation factor CDF4 in a coherent feed-forward loop (cFFL). These findings and mathematical modeling provide a mechanistic framework for WOX5 function in the root stem cell niche.