28 May 2024

Associations of Urine and Plasma Metabolites with Kidney Failure and Death in a CKD Cohort

Steinbrenner I, Schultheiss UT, Bächle H, Cheng Y, Behning C, Schmid M, Yeo WJ, Yu B, Grams ME, Schlosser P, Stockmann H, Gronwald W, Oefner PJ, Schaeffner E, Eckardt KU, Köttgen A, Sekula P; GCKD Investigators.

Am J Kidney Dis. 2024; doi: 10.1053/j.ajkd.2024.03.028.

We explored metabolites in plasma and urine for their association with kidney disease. Metabolomic analyses revealed 182 metabolites associated with progression or death. Our comprehensive screen serves as a valuable foundation for future investigations into kidney disease biomarkers.