Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

Qiu D, Gu C, Liu G, Ritter K, Eisenbeis VB, Bittner T, Gruzdev A, Seidel L, Bengsch B, Shears SB, Jessen HJ.

Chem Sci. 2022; doi: 10.1039/d2sc05147h

Capillary electrophoresis mass spectrometry is applied to profile inositol phosphates and pyrophosphates in mouse tissues, patient biopsies, and PBMCs. We discover previously undescribed signalling molecules and assign them to specific tissue and cell types.