CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells.

Adlung L, Stapor P, Tönsing C, Schmiester L, Schwarzmüller LE, Postawa L, Wang D, Timmer J, Klingmüller U, Hasenauer J, Schilling M.

Cell Rep 2021; doi: 10.1016/j.celrep.2021.109507

Cell-to-cell variability is analysed in the response of precursors of red blood cells to the hormone Epo. Experimental data and mathematical modeling show that the survival of an individual cell depends on the amount of signal transduction proteins and the size of the cell.