30 Jun 2025

Circulating Proteins for Prediction of Kidney Disease Progression and Cardiovascular Outcomes: Individual Participant Data Meta-Analysis of Four Cohorts

Lopez-Silva C, Surapaneni A, Coresh J, Chen TK, Schlosser P, Rhee EP, Waikar SS, Schmidt IM, Deo R, Ganz P, Dubin R, Ramachandran VS, Kimmel PL, Schrauben S, Parikh CR, Bonventre JV, Dobre M, Rao PS, Ricardo AC, Weir MR, Grams ME; CRIC Study Investigators.

Am J Nephrol. 2025; doi: 10.1159/000547138. Online ahead of print.

We evaluated the potential prognostic enrichment of KIM-1, TNFRSF1A and TNFRSF1B in four cohorts to check whether they may be useful in identifying high-risk patients for cardiovascular/kidney clinical trial enrollment in other important subgroups.