CIBSS - Centre for integrative Biological Signalling Studies CIBSS

CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson's disease

Frosch M, Amann L, Prinz M.

Nat Commun. 2023; doi: 10.1038/s41467-023-39061-9.

In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4+ T cell recruitment and mediate an α-syn-induced inflammatory makeup.