CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Development Cell, Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface

Philippe Petry 1 2 13, Alexander Oschwald 1 2 13, Simon Merkt 3 4 5, Thien-Ly Julia Dinh 2 6, Geoffroy Andrieux 7, Cylia Crisand 1, Hannah Botterer 1, Elisa Nent 8, Neil Paterson 8, Monique Havermans 1 2, Roman Sankowski 1, Oliver Schilling 6, Melanie Boerries 7 9, Lukas Amann 1,Olaf Groß 1 10, Andreas Schlitzer 3, Marco Prinz 1 10, Tim Lämmermann 8 11, Katrin Kierdorf 1 10 12 14

Science Direct. 2025 https://doi.org/10.1016/j.devcel.2025.08.012

Microglia progenitors enter the embryonic CNS from the surrounding mesenchyme. ECM-integrin interactions facilitate microglial progenitor migration into the CNS and this early microglial colonization of the CNS is talin-1 dependent.