CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome

Domschke K, Schiele MA, Crespo Salvador Ó, Zillich L, Lipovsek J, Pittig A, Heinig I, Ridderbusch IC, Straube B, Richter J, Hollandt M, Plag J, Fydrich T, Koelkebeck K, Weber H, Lueken U, Dannlowski U, Margraf J, Schneider S, Binder EB, Ströhle A, Rief W, Kircher T, Pauli P, Hamm A, Arolt V, Hoyer J, Wittchen HU, Erhardt-Lehmann A, Köttgen A, Schlosser P, Deckert J.

Mol Psychiatry. 2025; doi: 10.1038/s41380-025-03038-5. Online ahead of print.

Epigenetic mechanisms e.g. DNA methylation are hypothesized to play a pivotal role in the pathogenesis of anxiety disorders and relate to treatment response. An EWAS was performed in the so far largest longitudinal sample of patients with anxiety disorders treated with exposure-based CBT.