Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi
Bertolini MS, Cline SE, Chiurillo MA, Mantilla BS, Eidex A, Crowe LP, Qiu D, Jessen HJ, Saiardi A, Docampo R.
In this paper, the lipid-independent generation of soluble inositol phosphates is demonstrated in trypanosomes. This involves the de novo synthesis of inositol from glucose.
