CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase

Kim W, Kim E, Min H, Kim MG, Eisenbeis VB, Dutta AK, Pavlovic I, Jessen HJ, Kim S, Seong RH

Proc Natl Acad Sci U S A. 2019;116(26):12952-12957

Proc Natl Acad Sci U S A.         online article

It is demonstrated that Bruton´s tyrosine kinase is physiologically regulated by inositol hexakisphosphate involved in BCR signaling. B cells devoid of higher inositol phosphates cannot mount the immune response against T-cell independent antigens.