Proc Natl Acad Sci U S A. 2019;116(26):12952-12957


Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase
Proc Natl Acad Sci U S A. online article
It is demonstrated that Bruton´s tyrosine kinase is physiologically regulated by inositol hexakisphosphate involved in BCR signaling. B cells devoid of higher inositol phosphates cannot mount the immune response against T-cell independent antigens.